America’s President Joe Biden will on Wednesday unveil his multi-trillion dollar rescue plan for the economy outlining the details and scope of the much touted major infrastructure-and-jobs program.

The announcement, which will be made in Pittsburgh, will offer the first concrete details of Biden’s plan to overhaul federal spending while at the same time expanding and reorienting the US government to make America strong and economically rigid. However, Biden will not have an easy time convincing Congress of his rescue plan thus setting the stage for a bitter fight on Capitol Hill that could define his presidency.

To succeed, Biden will have to convince the public and lawmakers on a multi-trillion-dollar investment in infrastructure and social safety nets, along with a revamp of the tax code to help address funding needs and widening inequality. Later this week, Biden will offer the first glimpse of his 2022 budget, which promises to redirect federal funds to areas such as climate change and health care.

Major focus on infrastructure in reviving the economy

While Biden has made clear his plans will include tax-policy changes to help fund what aides have laid out as a roughly US$3 trillion long-term program. The American President has been trumpeting that infrastructure is “the place where we will be able to significantly increase American productivity, at the same time providing really good jobs.”

It has already been said that Biden will not include in his budget details a comprehensive breakdown about the agency-by-agency spending increases the administration is seeking. White House Press Secretary, Jen Psaki told Fox News on Sunday that Biden will present his infrastructure plan this week with social initiatives including health care and child care later in April.

Republican lawmakers are already greeting Biden’s intentions with stiff opposition, as they look to build a case against tax and spending increases ahead of the mid-term elections in 2022. The GOP needs just one seat in the Senate and a handful in the House to retake control of Congress and cripple the rest of the Biden agenda.

Cancer research will be a priority area in the budget

Biden has signaled that one priority for his administration will be the fight against cancer, an issue with personal salience for Biden, who lost his son Beau to glioblastoma. During a visit to a cancer hospital in Ohio this month, Biden floated the idea of a federally backed health research agency that mirrored the experimental role DARPA plays for the defense industry.

This agency, he said would “deliver health breakthroughs to find cures for cancer and other diseases by investing billions of dollars that companies are not willing to.” That effort would likely be in addition to a boost he’s pledged for the National Institute of Health (NIH) National Cancer Institute, building on the US$1.8 billion he secured as vice president for a “moonshot” type initiative launched in the wake of his son’s death.

Other areas of NIH and the Centers for Disease Control (CDC) are also expected to receive a funding boost, with money focused on emerging disease detection, treatment research, and stockpiles of supplies and equipment depleted during the COVID-19 crisis.

The budget could provide some insight into how or whether the president aims to boost efforts to process child migrants at the US-Mexico border or address Democratic priorities like prescription-drug prices and health care costs.

The 2022 budget proposal this week won’t contain the tax revenue, mandatory entitlement-spending figures and deficit-reduction proposals that come in the usual full 10-year budget vision from the White House. That information is expected later this spring.